RNA “Specialists” Activate Nerve Regeneration
Researchers identify a genetic "switch" that is only active when nerves are injured 24.01.2019 Regeneration of neuronal branches, surrounded by glia cells (whose nuclei are marked by blue dots), in a mouse sciatic nerve, seven days (top) and 25 days (bottom) after...
A gift for drug discovery
Weizmann establishes the Dr. Barry Sherman Institute for Medicinal Chemistry DATE: JANUARY 21, 2019 SOURCE: WEIZMANN HOMEPAGE It is the purview of pharmaceutical companies to develop potential medications, then market and sell them to patients. And in the halls of...
No Rest for Weary Immune Cells
An advanced method for investigating the activity of single cells could lead to better immunotherapy drugs 14.01.2019 Postdoctoral fellows (l-r) Drs. Hanji Li, Yaniv Lubling and Ido Yofe Why do some cancer patients respond well to immunotherapy, while others do not?...
Where the Blood-Brain Barrier Breaks Down
The cells that keep blood vessels in the pituitary permeable to hormones may hold the key to future drug delivery 07.01.2019 Blood vessels of the zebrafish pituitary before (left) and after (right) inhibition of permeability The so-called blood-brain barrier is a...
Lowering the Handbrakes on Stem Cell Production
Cells that are reprogrammed to become stem cells benefit when a protein complex is removed 03.01.2019 Stem cell colonies lacking the protein Gatad2a (the two left-hand images) compared to normal stem cells (the two on the right). Green staining shows proteins typical...
The Immune System’s Fountain of Youth
Helping the immune system clear away old cells in aging mice helped restore youthful characteristics 31.12.2018 Drug treatment eliminates senescent cells from tissues of old mice. The blue staining shows senescent cells in lung and liver tissue. The amount of the...
It’s a Stretch: Giving Direction to Blood Vessels
Scientists from the Technion - Israel Institute of Technology and the Weizmann Institute of Science reveal the mechanical forces that influence the spatial organization of blood vessels 13.12.2018 An example of well-oriented blood vessels generated in the laboratory,...
The Importins of Anxiety
The discovery of a new neural mechanism underlying anxiety points to possible treatments 11.12.2018 In genetically engineered mice lacking the protein called importin alpha-5 (right), a molecule called MeCP2 (red), known to affect anxiety behaviors, stayed on the...
Profiling a Killer in Warm Blood
Israeli scientists and physicians develop a new technology for profiling the unique genetic makeup of myeloma tumor cells that will allow better diagnosis and treatment 06.12.2018 Tumor heterogeneity, clonal evolution and therapy resistance revealed using single cell...
Dr. Barry Sherman Institute for Medicinal Chemistry
The Weizmann Institute of Science establishes the Dr. Barry Sherman Institute for Medicinal Chemistry 04.12.2018 In an effort to advance basic research insights for the benefit of therapeutic discoveries, the Weizmann Institute of Science is establishing the Dr. Barry...